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Title: | Cardiovascular considerations before cancer therapy: gaps in evidence and JACC: Cardiooncology expert panel recommendations. | Authors: | Raisi-Estabragh Z.;Murphy A.C.;Ramalingam S.;Scherrer-Crosbie M.;Lopez-Fernandez T.;Reynolds K.L.;Aznar M.;Lin A.E.;Libby P.;Cordoba R.;Bredsen-Masley C.;Wechalekar A.;Apperley J.;Cheng R.K.;Manisty C.H. | Monash Health Department(s): | Cardiology (MonashHeart) | Institution: | (Raisi-Estabragh) William Harvey Research Institute, National Institute for Health and Care Research Barts Biomedical Research Centre, Queen Mary University of London, London, United Kingdom (Raisi-Estabragh, Manisty) Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom (Murphy) Victorian Heart Hospital, Victoria, Australia (Ramalingam) Cardio-Oncology Service, Royal Brompton Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom (Scherrer-Crosbie) Division of Cardiology, The Hospital of the University of Pennsylvania, Philadelphia, PA, United States (Lopez-Fernandez) Hospital Universitario La Paz, Instituto de Investigacion La Paz-IdiPaz, Madrid, Spain (Lopez-Fernandez) Hospital Universitario Quiron Pozuelo, Madrid, Spain (Reynolds) Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States (Aznar) Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom (Lin) Department of Medicine, Division of Cardiology, Section of Cardio-Oncology and Immunology, University of California-San Francisco, San Francisco, CA, United States (Libby) Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States (Cordoba) Fundacion Jimenez Diaz University Hospital, Health Research Institute Instituto de Investigacion Sanitaria de la Fundacion Jimenez Diaz, Madrid, Spain (Bredsen-Masley) Division of Hematology/Oncology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada (Wechalekar) Department of Haematology, University College London Hospitals NHS Trust, London, United Kingdom (Apperley) Department of Clinical Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom (Apperley) Centre for Haematology, Imperial College London, London, United Kingdom (Cheng) Division of Cardiology, University of Washington Medical Center, Seattle, Washington, United States (Manisty) Institute of Cardiovascular Science, University College London, London, United Kingdom |
Issue Date: | 11-Oct-2024 | Copyright year: | 2024 | Publisher: | Elsevier Inc. | Place of publication: | United States | Publication information: | JACC: CardioOncology. 6(5) (pp 631-654), 2024. Date of Publication: October 2024. | Journal: | JACC: CardioOncology | Abstract: | Baseline cardiovascular assessment before the initiation of potentially cardiotoxic cancer therapies is a key component of cardio-oncology, aiming to reduce cardiovascular complications and morbidity in patients and survivors. Recent clinical practice guidelines provide both general and cancer therapy-specific recommendations for baseline cardiovascular toxicity risk assessment and management, including the use of dedicated risk scores, cardiovascular imaging, and biomarker testing. However, the value of such interventions in altering disease trajectories has not been established, with many recommendations based on expert opinion or Level of Evidence: C, studies with a potential for high risk of bias. Advances in understanding underlying mechanisms of cardiotoxicity and the increased availability of genetic and immunologic profiling present new opportunities for personalized risk assessment. This paper evaluates the existing evidence on cardiovascular care of cancer patients before cardiotoxic cancer therapy and highlights gaps in evidence and priorities for future research.Copyright © 2024 The Authors | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1016/j.jaccao.2024.07.017 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/52582 | Type: | Review | Subjects: | cancer patient cancer therapy cardio-oncology cardiotoxicity cardiovascular disease malignant neoplasm |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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