Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/52771
Conference/Presentation Title: COVID-19 MRNA vaccine associated myocarditis - 1 year follow-up from a tertiary children's hospital in Australia.
Authors: Varma S.K.;Carrigan L.;Ditchfield M.;Rao S.
Institution: (Varma, Carrigan, Ditchfield, Rao) Monash Health, Clayton, Australia
Presentation/Conference Date: 19-Nov-2024
Copyright year: 2024
Publication information: Cardiology in the Young. Conference: 8th World Congress of Pediatric Cardiology and Cardiac Surgery, WCPCCS 2023. Washington, DC United States. 34(Supplement 1) (pp S1044), 2024. Date of Publication: May 2024.
Journal: Cardiology in the Young
Abstract: Background: Myocarditis in adolescents and young adults is a recognized rare complication after COVID-19 vaccination. We describe cardiac sequelae at 1 year follow-up for vaccine-associated myocarditis (VAM) from a tertiary Children's Hospital in Australia. Case Description: Methods: Prospective surveillance of VAM cases between January 2022 and May 2023. Myocarditis was defined by standard criteria. Clinical findings, ECG, echocardiogram and Cardiac MRI (CMR) findings were evaluated. Result(s): 33 cases were included (median age at presentation 14.6 years (IQR 13- 16.4), 82% male). 29 out of 33 (87.9%) had complete follow up including repeat CMR after 1 year (median 420 days, IQR 407-439 days). There were no deaths. There were no patients with symptoms at follow up. ECG changes typical of pericarditis (8/33) had resolved early in the course of the illness, with no arrhythmias recorded. Echocardiography showed normal left ventricular systolic function at presentation in 29 patients and mildly impaired LVF in 4, all of which resolved within 2 days and remained normal at follow up. CMR was performed early (median 2 days; IQR 1- 2.5 days) with abnormal findings in 27 of 33 patients (81%). Repeat CMR after 1 year showed that 21 out 29 (72.4%) had late Gadolinium enhancement (LGE). There was no evidence of oedema. A decrease in LGE intensity or distribution was noted in 17/21 (81%). 24 patients with CMR abnormalities on their acute scans have had repeat CMR after 1 year; complete resolution of LGE was noted in only 4 patients (16.7%). Conclusion(s): None of the patients had persistent clinical or echocardiographic abnormalities after acute VAM. Majority of the patients had fibrosis on CMR after 1 year follow up with a decrease in LGE intensity or distribution compared to their acute CMR studies. While it is heartening to note that all patients have remained well, the potential long-term consequences of fibrosis are unknown and warrant further surveillance.
Conference Name: 8th World Congress of Pediatric Cardiology and Cardiac Surgery, WCPCCS 2023
Conference Start Date: 2023-08-27
Conference End Date: 2023-09-01
Conference Location: Washington, DC, United States
DOI: http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1017/S1047951124024478
URI: https://repository.monashhealth.org/monashhealthjspui/handle/1/52771
Type: Conference Abstract
Subjects: cardiovascular magnetic resonance
echocardiography
edema
electrocardiography
heart arrhythmia
myocarditis
pericarditis
SARS-CoV-2 vaccine
Type of Clinical Study or Trial: Observational study (cohort, case-control, cross sectional, or survey)
Appears in Collections:Conferences

Show full item record

Page view(s)

44
checked on Mar 13, 2025

Google ScholarTM

Check


Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.