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https://repository.monashhealth.org/monashhealthjspui/handle/1/53106| Title: | An expert consensus statement on biomarkers of ageing for use in intervention studies. | Authors: | Perri G.;French C.;Agostinis-Sobrinho C.;Anand A.;Antarianto R.D.;Arai Y.;Baur J.A.;Cauli O.;Clivaz-Duc M.;Colloca G.;Demetriades C.;de Lucia C.;Di Gessa G.;Diniz B.S.;Dotchin C.L.;Eaglestone G.;Elliott B.T.;Espeland M.A.;Ferrucci L.;Fisher J. ;Grammatopoulos D.K.;Hardiany N.S.;Hassan-Smith Z.;Hastings W.J.;Jain S.;Joshi P.K.;Katsila T.;Kemp G.J.;Khaiyat O.A.;Lamming D.W.;Gallegos J.L.;Madeo F.;Maier A.B.;Martin-Ruiz C.;Martins I.J.;Mathers J.C.;Mattin L.R.;Merchant R.A.;Moskalev A.;Neytchev O.;Ni Lochlainn M.;Owen C.M.;Phillips S.M.;Pratt J.;Prokopidis K.;Rattray N.J.W.;Rua-Alonso M.;Schomburg L.;Scott D. ;Shyam S.;Sillanpaa E.;Tan M.M.C.;Teh R.;Tobin S.W.;Vila-Cha C.J.;Vorluni L.;Weber D.;Welch A.;Wilson D.;Wilson T.;Zhao T.;Philippou E.;Korolchuk V.I.;Shannon O.M. | Monash Health Department(s): | Monash University - School of Clinical Sciences at Monash Health | Institution: | (Perri, Mathers, Shannon) Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom (French) School of Health Sciences, University of Manchester, Manchester, United Kingdom (Agostinis-Sobrinho, Rua-Alonso, Vila-Cha) Sport Physical Activity and Health Research & Innovation Center (SPRINT), Guarda, Portugal (Agostinis-Sobrinho) Health Research and Innovation Science Centre, Klaipeda University, Lithuania (Anand) Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom (Antarianto) Department of Histology, Faculty of Medicine Universitas Indonesia, Indonesia (Antarianto) Stem Cell and Tissue Engineering, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia (Arai) Center for Supercentenarian Medical Research, Keio University School of Medicine, Japan (Baur) Department of Physiology and Institute for Diabetes, Obesity, Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States (Cauli) Department of Nursing, University of Valencia, Valencia, Spain (Cauli) Chair of Active Ageing. University of Valencia, Valencia, Spain (Clivaz-Duc) Sierre Valais Switzerland (Colloca) Dipartimento di Diagnostica per Immagini, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (Demetriades) Max Planck Institute for Biology of Ageing (MPI-AGE), Cologne, Germany (Demetriades) University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany (de Lucia) Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway (de Lucia) Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom (Di Gessa) Department of Epidemiology & Public Health, University College London, London, United Kingdom (Diniz) UConn Center on Aging & Department of Psychiatry, University of Connecticut Medical School, Farmington, CT, United States (Dotchin, Owen, Tan) Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom (Dotchin) Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom (Eaglestone) Institute for Lifecourse Development, University of Greenwich, London, United Kingdom (Elliott, Mattin) Ageing Biology & Age Related Diseases, School of Life Sciences, University of Westminster, London, United Kingdom (Espeland) Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, United States (Ferrucci) Translational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States (Fisher) School of Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (Grammatopoulos) Biomedical Sciences, Warwick Medical School, University of Warwick, United Kingdom (Grammatopoulos) Institute of Precision Diagnostics, University Hospital Coventry and Warwickshire NHS Trust, West Midlands, Coventry, United Kingdom (Hardiany) Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia (Hassan-Smith) Institute for Metabolism and Systems Research, University of Birmingham and Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom (Hastings) Department of Nutrition, Texas A&M University, College Station, TX, United States (Jain) World Public Health Nutrition Association, United Kingdom (Joshi) Humanity Inc, Humanity, 177 Huntington Ave, Humanity Inc - 91556, Boston, MA, United States (Joshi) Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom (Katsila) Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece (Kemp) Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom (Khaiyat) School of Health and Sport Sciences, Liverpool Hope University, Liverpool, United Kingdom (Lamming) Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States (Gallegos) Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom (Gallegos) Northumbria University, Newcastle upon Tyne, United Kingdom (Madeo) Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria (Madeo) Field of Excellence BioHealth, University of Graz, Graz, Austria (Maier) Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (Maier) Centre for Healthy Longevity, National University Health System, 10 Medical Drive, Singapore (Martin-Ruiz) BioScreening Core Facility, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (Martins) Sarich Neuroscience Research Institute, Edith Cowan University, Verdun Street, Australia (Merchant) Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (Moskalev) Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation (Moskalev) Research Clinical Center of Gerontology of the National Research Medical University, Moscow, Russian Federation (Neytchev) University of Glasgow, College of Medical, Veterinary & Life Sciences, School of Molecular Biosciences, Glasgow, United Kingdom (Ni Lochlainn) King's College London, Department of Twin Research and Genetic Epidemiology, London, United Kingdom (Phillips) McMaster University, Department of Kinesiology, Hamilton, ON, Canada (Pratt) Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester, United Kingdom (Prokopidis) Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom (Rattray) Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, United Kingdom (Rua-Alonso) Performance and Health Group, Faculty of Sports Sciences and Physical Education, Department of Physical Education and Sports, University of A Coruna, A Coruna, Spain (Schomburg) Institute for Experimental Endocrinology, Berlin, Germany (Scott) Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia (Scott) School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia (Shyam) Departament de Bioquimica i Biotecnologia, Grup Alimentacio, Nutricio, Desenvolupament i Salut Mental, Unitat de Nutricio Humana, Universitat Rovira i Virgili, Reus, Spain; & Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain (Shyam) Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, Spain (Sillanpaa) Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyvaskyla, Finland (Sillanpaa) Wellbeing Services County of Central Finland, Finland (Tan) Department of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, De Crespigny Park, London, United Kingdom (Teh) Department of General Practice and Primary Health Care, Faculty of Medicine and Health Sciences, University of Auckland (Tobin) Trent Centre for Aging & Society, Trent University, Peterborough, ON, Canada (Vorluni) Independent Researcher, Human Physiology and Integrative Medicine (Weber) Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE), Nuthetal, Germany (Welch) Centre for Population Health Research, Faculty of Health, University of East Anglia, Norwich, United Kingdom (Wilson) Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom (Wilson) Department of Life Sciences, Aberystwyth University, United Kingdom (Zhao) Institute of Zoology Chinese Academy of Sciences, Beijing, China (Philippou) Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus (Philippou) Department of Nutritional Sciences, King's College London, United Kingdom (Korolchuk) Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom |
Issue Date: | 9-Jan-2025 | Copyright year: | 2024 | Place of publication: | United States | Publication information: | The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences.. (no pagination), 2024. Date of Publication: 21 Dec 2024. | Journal: | The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. | Abstract: | Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method. A three-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of ageing. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of ageing. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was >=70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (e.g., insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (e.g., high sensitivity c-reactive protein, interleukin-6), functional (e.g., muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (e.g., DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of ageing which may be used as outcome measures in intervention studies. Future ageing research should identify which combination of these biomarkers has the greatest utility.Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of the Gerontological Society of America. | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1093/gerona/glae297 | PubMed URL: | 39708300 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/53106 | Type: | Article | Subjects: | frailty inflammation muscle strength |
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