Correlation between PI-RADS score and prostate core biopsy histopathology.

Abstract

Background: Traditionally, prostate cancer (PCa) diagnosis relies on invasive biopsies. The introduction of the Prostate Imaging-Reporting and Data System (PI-RADS) has improved MRI interpretation, assisting with the detection and risk stratification of clinically-significant prostate cancer (csPCa).1,2 Aims: This project aims to investigate the role and correlation between PI-RADS and prostate core biopsy histopathology in staging csPCa at a large tertiary hospital. Method(s): We conducted a retrospective analysis of 106 patients at Monash Health who underwent MRI and subsequent prostate core biopsy between 1 January 2022 and 31 December 2022. The following characteristics were included: maximum PI-RADS score for each patient and ISUP grade groups of histopathology. Result(s): Of the 106 biopsies, 94% were PI-RADS 3,4 and 5 lesions, which had mean ISUP grades of 1.87, 1.73 and 7.75 respectively. Using Spearman's rank correlation coefficient, the rho coefficient was 0.3564 (p-value = 0.00018), demonstrating a strong correlation between ISUP grades and PI-RADS scores. Discussion(s): This study supports the role of PI-RADS as a triage tool for accurate detection and risk stratification of suspected csPCa. The statistically significant positive relationship between ISUP and PI-RADS scores reinforces the accuracy of MRI in diagnosing PCa and expediting treatment. References 1. Lomas DJ, Ahmed HU. All change in the prostate cancer diagnostic pathway. Nat Rev Clin Oncol 2020; 17: 372-81. 2. Gupta R, Mahajan M, Sharma P. Correlation between prostate imaging reporting and Data System Version 2, Prostate-Specific Antigen Levels, and local staging in biopsy-proven carcinoma prostate: a retrospective study. Int J Appl Basic Med Res 2021; 11: 32-5.Copyright © 2024