Patterns of ovarian cancer care and overall survival in Australia: a prospective study from the national gynae-oncology registry (NGOR).

Abstract

Introduction Ovarian cancer (OC) in Australia has the highest gynaecological cancer mortality. Data on patterns of care (POC) compared with 'best practice' is limited. This study aims to describe POC and overall survival (OS) for women with newly diagnosed OC using data from the Australian National Gynae-Oncology Registry (NGOR). Methods Clinical Quality Indicators (CQIs) reflecting 'best practice' were sourced from the NGOR sites for all patients with newly diagnosed OC between 2017-2024. Results A total of 2643 OC patients were analysed. Across the 15 CQIs, the highest compliance included the proportion of patients discussed at a multi-disciplinary meeting (n=2543, 96%) and diagnosed by cytology or histology (n=747, 89%) prior to commencing neoadjuvant chemotherapy. In a multivariate analysis, the CQIs associated with significantly improved rates of OS were in patients receiving doublet chemotherapy, genetic testing, and in patients who had primary or interval debulking surgery with no macroscopic residual disease. Overall survival acrosss all stages at 3-years and 5- years was 66% and 50% respectively. Survival by stage is shown below: Conclusion/Implications This is the most comprehensive country- wide analysis demonstrating POC compliance with contemporary 'best practice' in Australia. Reporting of CQIs will likely result in improved outcomes for women with newly diagnosed OC.