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https://repository.monashhealth.org/monashhealthjspui/handle/1/57884| Title: | Impact of Sex on Residual Angina After Percutaneous Coronary Interventions. | Authors: | Rivero F.;Collet C.;Munhoz D.;Ikeda K.;Mizukami T.;Hada M.;Johnson N.P.;Kakuta T.;Bouisset F.;Kechichian A.;Stalikas N.;Corradetti S.;Barbato P.;De Bruyne B.;Ali Z.;Jeremias A.;Perera D.;Amano T.;Johnson T.;Collison D.;Ko B. ;Berry C.;Campo G.;da Costa B.R.;Storozhenko T.;Sakai K.;Zimmermann F.M.;Eftekhari A.;Nakayama M.;Escaned J.;Adjedj J.;Yong A.;Desta L.;Fournier S.;Christiansen E.H.;Fearon W.F.;van Nunen L.X.;Galante D.;Leone A.M.;Arslani K.;Engstrom T.;Biscaglia S.;Ando H.;Shinke T.;Matsuo H.;Sonck J.;Brouwers S. | Monash Health Department(s): | Cardiology (MonashHeart) | Institution: | (Hada, Mizukami, Ikeda, Munhoz, Brouwers, Sonck, Sakai, Storozhenko, De Bruyne, Corradetti, Stalikas, Kechichian, Bouisset, Collet) Cardiovascular Center Aalst, AZORG, Aalst, Belgium (Hada, Kakuta) Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan (Mizukami) Division of Clinical Pharmacology, Department of Pharmacology, Showa Medical University, Tokyo, Japan (Ikeda) Department of Cardiology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan (Brouwers) Department of Experimental Pharmacology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium (Matsuo) Department of Cardiovascular Medicine, Gifu Heart Center, Gifu, Japan (Shinke, Sakai) Department of Medicine, Division of Cardiology, Showa Medical University School of Medicine, Tokyo, Japan (Ando, Amano) Department of Cardiology, Aichi Medical University, Aichi, Japan (Ko) Victorian Heart Hospital, Monash University, Melbourne, VIC, Australia (Biscaglia, Campo) Cardiology Unit, Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy (Rivero) Cardiac Department, Hospital Universitario de La Princesa, Madrid, Spain (Engstrom) Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (Arslani, Leone) Department of Cardiovascular and Pneumological Sciences, Catholic University of the Sacred Heart, Rome, Italy (Leone, Galante) Center of Excellence in Cardiovascular Sciences, Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy (van Nunen) Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands (Fearon) Division of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine and VA Palo Alto Health Care System, Palo Alto, CA, United States (Christiansen) Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (Fournier, De Bruyne) Department of Cardiology, University Hospital of Lausanne, Lausanne, Switzerland (Desta) Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden (Yong) Concord Repatriation General Hospital, University of Sydney, Sydney, NSW, Australia (Adjedj) Department of Cardiology, Arnault Tzanck Institute, Saint Laurent du Var, France (Escaned) Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos, Complutense University, Madrid, Spain (Nakayama) Department of Cardiology, Tokyo D Tower Hospital, Tokyo, Japan (Nakayama) Department of Cardiology, Nadogaya Hospital, Kashiwa, Japan (Eftekhari) Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark (Zimmermann) Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, Netherlands (Sakai, Jeremias, Ali) St Francis Hospital and Heart Center, Roslyn, NY, United States (Storozhenko) Department of Prevention and Treatment of Emergency Conditions, L.T. Malaya Therapy National Institute NAMSU, Kharkiv, Ukraine (da Costa) Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (da Costa) Clinical Epidemiology & Health Care Research, Institute of Health Policy and Management Evaluation (IHPME), University of Toronto, Toronto, ON, Canada (Berry, Collison) School Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom (Berry, Collison) NHS Golden Jubilee Hospital, Clydebank, United Kingdom (Johnson) University Hospitals Bristol & Weston NHS Foundation Trust, Bristol, United Kingdom (Perera) School of Cardiovascular Medicine and Sciences, St Thomas' Hospital Campus, King's College London, London, United Kingdom (Barbato, Corradetti, Kechichian) Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy (Bouisset) Department of Cardiology, Institute CARDIOMET, CHU-Toulouse, Toulouse, France (Johnson) Department of Medicine, Division of Cardiology, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Weatherhead PET Center, Houston, TX, United States (Collet) Division of Cardiology, New York Presbyterian Hospital Columbia University, New York, NY, United States (Collet) Clinical Trial Center, Cardiovascular Research Foundation, New York, NY, United States |
Issue Date: | 23-Mar-2026 | Copyright year: | 2026 | Publisher: | John Wiley and Sons Inc | Place of publication: | United States | Publication information: | Catheterization and Cardiovascular Interventions. 107(4) (pp 987-996), 2026. Date of Publication: 01 Mar 2026. | Journal: | Catheterization and Cardiovascular Interventions | Abstract: | Background: Sex-related differences in the clinical presentation of coronary artery disease (CAD) are well recognized. The pullback pressure gradient (PPG) characterizes pathophysiological CAD patterns as focal or diffuse. Objective(s): To evaluate the influence of sex on residual angina at one year after percutaneous coronary intervention (PCI), stratified by PPG. Method(s): We performed a sub-analysis of PPG Global, a multicenter, prospective, single-arm study. All patients had hemodynamically significant CAD (fractional flow reserve [FFR] <= 0.80) and underwent a manual FFR pullbacks to calculate PPG before PCI. Patient-reported outcomes were collected using the 7-item Seattle Angina Questionnaire (SAQ-7) at baseline and 1-year follow-up. Result(s): We included 814 patients (205 [25.2%] women and 609 [74.8%] men). Women were significantly older than men (70 +/- 10 years vs. 67 +/- 10 years p < 0.001). Baseline FFR were comparable between sexes (0.68 +/- 0.13 vs. 0.66 +/- 0.12, p = 0.098), but women had a more focal CAD compared to men (PPG 0.66 +/- 0.15 vs. 0.63 +/- 0.15, p = 0.047). Post PCI-FFR was higher in women than men (0.88 +/- 0.07 vs. 0.87 +/- 0.07, p = 0.041); however, angina at 1 year was more frequent in women (SAQ angina frequency score 94 +/- 12 vs. 96 +/- 10, p = 0.041). Conclusion(s): Despite having a more focal CAD pattern and achieving higher post-PCI FFR, women report more residual angina than men at 1-year follow-up. Trial Registration: ClinicalTrials.gov NCT04789317.Copyright © 2025 Wiley Periodicals LLC. | DOI: | https://dx.doi.org/10.1002/ccd.70419 | PubMed URL: | 41408672 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/57884 | Type: | Article |
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