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https://repository.monashhealth.org/monashhealthjspui/handle/1/58094| Title: | Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study. | Authors: | Peel T.N.;Cowan R.;Alcorn K.;Brischetto A.;Mahony A.;Redmond A.;Chakravorty A.;Meher-Homji Z.;Yuson C.;Crawford S.;Weeks G.;Ponnampalavanar S.S.S.;Katelaris C.;Tran P.;O'Hern J.;Godsell J.;Rose M.;Sandaradura I.;New D.;Holland C.;Cutfield T.;Coghill S.;Hand C.;Williams J.;Bishop J.;Lambros B.;Day C.;Ierano C.;Holmes N.E.;Roberts J.A.;Fernando S.L.;Klaic M.;Trubiano J.A.;Fletcher L.R.;Peter J.;Powell N.;Barnes S. ;Li P.H.;Copaescu A.M.;Turner N.A.;James F.;Sullivan R.;Masoum M.S.;Rawlins M.;Mackay G.;Smith B.J.;Kilfoyle P.;Mitri E.A.;Forster D.;Vogrin S.;Paynter C. | Monash Health Department(s): | Respiratory and Sleep Medicine Infectious Diseases and Clinical Microbiology |
Institution: | (Roberts) Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia (Roberts) UR UM 103, University of Montpellier, Division of Anesthesia Critical Care and Emergency and Pain Medicine, Nimes University Hospital, Nimes, France (Fernando) Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia (Fernando) Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, NSW, Australia (Mitri, Vogrin, Copaescu, James, Rose, Godsell, Holmes, Trubiano) Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia (Mitri, Vogrin, Copaescu, James, Rose, Mahony, Ierano, Holmes, Trubiano) Department of Infectious Diseases, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia (Mitri, Trubiano) National Allergy Centre of Excellence (NACE), Parkville, VIC, Australia (Paynter, Klaic) School of Health Sciences, University of Melbourne, Melbourne, VIC, Australia (Fletcher) Department of Anaesthesia, Austin Health, Heidelberg, VIC, Australia (Fletcher) Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia (Fletcher) Data Analytics Research and Evaluation (DARE) Centre, Austin Health, Heidelberg, VIC, Australia (Peter, Day) Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa (Peter, Day) Division of Allergology and Clinical Immunology, Department of Medicine, Faculty of Health Sciences, Groote Schuur Hospital, Cape Town, South Africa (Powell) Pharmacy Department, Royal Cornwall Hospitals NHS Trust, Truro, United Kingdom (Barnes) Monash Lung Sleep Allergy and Immunology, Monash Health, Clayton, VIC, Australia (Barnes) Department of Medicine, Monash University, Clayton, VIC, Australia (Li) Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong (Copaescu) Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada (Turner) Division of Infectious Diseases, Duke University Medical Center, Durham, NC, United States (Sullivan) Department of Infectious Diseases, St George Hospital, School of Clinical Medicine, UNSW Medicine and Health, Kogarah, NSW, Australia (Masoum) Department of Pharmacy and Department of Infectious Diseases, Royal Perth Hospital, Perth, WA, Australia (Rawlins) Department of Pharmacy, Fiona Stanley Hospital, Perth, WA, Australia (Mackay) Department of Pharmacy, Albury Wodonga Health, Albury, NSW, Australia (Smith) Department of Infectious Diseases, Western Health, Footscray, VIC, Australia (Kilfoyle) Pharmacy Department, Sunshine Coast University Hospital, QLD, Australia (Kilfoyle) Faculty of Medicine, School of Public Health, University of Queensland, Brisbane, QLD, Australia (Forster) Department of Infectious Diseases, Eastern Health, Box Hill, VIC, Australia (Rose, Lambros) Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (Cowan) Internal Medical Services, Grampians Health Service, Ballarat, VIC, Australia (Alcorn) Department of Infectious Diseases, Gold Coast Hospital and Health Service, Gold Coast, QLD, Australia (Alcorn) School of Medicine, Griffith University, Gold Coast, QLD, Australia (Brischetto) Infectious Diseases Unit, Redcliffe Hospital, Brisbane, QLD, Australia (Mahony) Infectious Diseases Unit, Bendigo Health, Bendigo, VIC, Australia (Mahony) Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia (Redmond) Infectious Diseases Unit, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia (Redmond) Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia (Redmond) School of Medicine, University of Queensland, Brisbane, QLD, Australia (Chakravorty) Infectious Diseases and General Medicine, St John of God Subiaco, Perth, WA, Australia (Meher-Homji) Department of Medicine, Latrobe Regional Health, Traralgon, VIC, Australia (Meher-Homji) School of Rural Health, Monash University, VIC, Australia (Yuson) Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA, Australia (Crawford) Department of Infectious Diseases, Royal Prince Alfred Hospital, Sydney, NSW, Australia (Crawford) School of Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia (Weeks) Pharmacy Department, Barwon Health, Geelong, VIC, Australia (Ponnampalavanar) Infectious Disease Unit, Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia (Ponnampalavanar) Department of Infection Control, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia (Katelaris) Immunology/Allergy Unit, Department of Medicine, Campbelltown Hospital and Western Sydney University, Sydney, NSW, Australia (Tran) Department of Pharmacy, Campbelltown Hospital, Sydney, NSW, Australia (O'Hern) Department of Infectious Diseases, Launceston General Hospital, Launceston, TAS, Australia (Godsell) Department of Clinical Immunology and Allergy, Royal Melbourne Hospital, Melbourne, VIC, Australia (Peel) Department of Infectious Diseases, Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, VIC, Australia (Sandaradura) Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW, Australia (Sandaradura) Sydney Infectious Diseases Institute, University of Sydney, Sydney, NSW, Australia (Sandaradura) Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia (New) Department of Infectious Diseases, Armadale Health Service, Perth, WA, Australia (Holland) Department of Infectious Diseases, Ipswich Hospital, Ipswich, QLD, Australia (Holland) Metro North Public Health Unit, Windsor, QLD, Australia (Holland) School of Public Health, University of Queensland, Herston, QLD, Australia (Cutfield) Department of Infectious Diseases, Middlemore Hospital, Auckland, New Zealand (Coghill) Department of Infectious Diseases, Lismore Base Hospital, Lismore, NSW, Australia (Hand) Pharmacy Department, Mildura Base Public Hospital, Mildura, VIC, Australia (Williams) Department of Infectious Diseases, Orange Health Service, Orange, NSW, Australia (Williams) School of Rural Health, Charles Sturt University, Orange, NSW, Australia (Bishop) Development & Improvement, East Grampians Health Service, Ararat, Victoria, Australia (Lambros) Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia (Lambros) National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (Lambros) Department of Nursing, School of Health Sciences, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Parkville, VIC, Australia (Ierano) National Centre for Antimicrobial Stewardship, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia (Roberts) University of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queenland, Australia (Roberts) Herston Infectious Diseases Institute, Metro North Health, Brisbane, QLD, Australia |
Issue Date: | 9-Apr-2026 | Copyright year: | 2026 | Place of publication: | United States | Publication information: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. (no pagination), 2026. Date of Publication: 01 Apr 2026. | Journal: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | Abstract: | In this international, multicenter prospective study, implementing penicillin direct oral challenge (DOC) using a digital toolkit was acceptable, feasible, and sustainable. Audit and feedback increased activity, particularly among pharmacists. Safety was maintained across heterogeneous DOC protocols, validating a pragmatic, scalable approach that supports local adaptation.Copyright © The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. | DOI: | https://dx.doi.org/10.1093/cid/ciag083 | PubMed URL: | 41921037 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/58094 | Type: | Article In Press |
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