Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/58217| Title: | Emerging role of non-coding RNAs as biomarkers and therapeutic targets in preterm infants with necrotizing enterocolitis. | Authors: | Garg P.M.;Malhotra A. | Monash Health Department(s): | Monash University - School of Clinical Sciences at Monash Health Paediatric - Neonatal (Monash Newborn) Hudson Institute - The Ritchie Centre |
Institution: | (Garg) Department of Pediatrics/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, NC, United States (Garg) Center of Precision Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States (Malhotra) Department of Paediatrics, Monash University, Melbourne, VIC, Australia (Malhotra) Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia (Malhotra) The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia |
Issue Date: | 21-Apr-2026 | Copyright year: | 2026 | Publisher: | Springer Nature | Place of publication: | United States | Publication information: | Pediatric Research. (no pagination), 2026. Date of Publication: 2026. | Journal: | Pediatric Research | Abstract: | Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants, marked by intestinal necrosis, inflammation, hemorrhage, and impaired repair. Despite advances in neonatal care, early diagnostics and targeted therapies remain limited. Emerging evidence shows that non-coding RNAs (ncRNAs), including microRNAs, long ncRNAs, and tRNA-derived fragments, regulate key inflammatory, cell-death, angiogenic, and immune pathways in NEC. Distinct ncRNA signatures correlate with histopathology, and plasma-derived exosomal ncRNAs show promise as early biomarkers. Human milk exosomal microRNAs exhibit protective effects, while ncRNA-microbiome interactions may influence disease susceptibility. Larger studies using high-throughput sequencing are needed to advance biomarker-driven precision care.Copyright © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2026. | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1038/s41390-026-04992-8 | PubMed URL: | 41991624 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/58217 | Type: | Article In Press | Subjects: | angiogenesis breast milk high throughput sequencing histopathology inflammation intestine necrosis microbial interaction necrotizing enterocolitis prematurity biological marker long untranslated RNA microRNA transfer RNA untranslated RNA |
| Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.