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https://repository.monashhealth.org/monashhealthjspui/handle/1/27376| Title: | An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. | Authors: | Monette S.;Holmes E.C.;Jolly C.J.;Weninger W.;Roediger B.;Lee Q.;Tikoo S.;Cobbin J.C.A.;Henderson J.M.;Jormakka M.;O'Rourke M.B.;Padula M.P.;Pinello N.;Henry M.;Wynne M.;Santagostino S.F.;Brayton C.F.;Rasmussen L.;Lisowski L.;Tay S.S.;Harris D.C.;Bertram J.F.;Dowling J.P.;Bertolino P.;Lai J.H.;Wu W.;Bachovchin W.W.;Wong J.J.-L.;Gorrell M.D.;Shaban B. | Institution: | (Roediger, Lee, Tikoo, Henderson, Jormakka, Pinello, Henry, Wynne, Tay, Bertolino, Wong, Gorrell, Jolly, Weninger) Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia (Cobbin, Holmes) Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia (O'Rourke) Mass Spectrometry Core Facility, University of Sydney, Sydney, NSW 2006, Australia (O'Rourke, Padula) Proteomics Core Facility, University of Technology Sydney, Ultimo, NSW 2007, Australia (Henry, Wynne) Laboratory Animal Services, University of Sydney, Sydney, NSW 2006, Australia (Santagostino, Monette) Laboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, United States (Brayton) Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States (Rasmussen) Cerberus Sciences, Thebarton, SA 5031, Australia (Lisowski) Children's Medical Research Institute, University of Sydney, Sydney, NSW 2006, Australia (Lisowski) Military Institute of Hygiene and Epidemiology, Biological Threats Identification and Countermeasure Centre, Pulawy 24-100, Poland (Harris) Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney, NSW 2006, Australia (Bertram) Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia (Dowling) Department of Anatomical Pathology, Monash Medical Centre, Clayton, VIC 3168, Australia (Lai, Wu, Bachovchin) Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, United States (Shaban) Australian Genomics Research Facility, Parkville, VIC 3000, Australia (Shaban) Melbourne Integrative Genomics, University of Melbourne, Parkville, VIC 3010, Australia (Weninger) Discipline of Dermatology, Faculty of Medicine and Health, University of Sydney, NSW 2006, Australia (Weninger) Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia (Weninger) Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria | Issue Date: | 20-Nov-2018 | Copyright year: | 2018 | Publisher: | Cell Press (E-mail: subs@cell.com) Cell Press |
Place of publication: | United States | Publication information: | Cell. 175 (2) (pp 530-543.e24), 2018. Date of Publication: 4 October 2018. | Journal: | Cell | Abstract: | The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans. A kidney parvovirus found in multiple laboratory mouse colonies causes spontaneous nephropathy and represents a new tool for studying chronic kidney disease.Copyright © 2018 Elsevier Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.cell.2018.08.013 | Link to associated publication: | Click here for full text options | PubMed URL: | 30220458 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30220458] | ISSN: | 0092-8674 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/27376 | Type: | Article | Subjects: | Australia cell inclusion *chronic kidney failure/et [Etiology] controlled study degenerative disease/et [Etiology] disease course female histopathology infection control *kidney fibrosis/et [Etiology] *kidney interstitium *kidney tubule disorder/et [Etiology] male metagenomics molecular pathology mouse nonhuman article *Parvoviridae parvovirus infection priority journal species distribution virus transmission *chronic tubulointerstitial nephropathy/et [Etiology] *mouse kidney parvovirus animal tissue North America animal cell adaptive immunity *kidney fibrosis / *etiology *kidney interstitium *kidney tubule disorder / *etiology male metagenomics molecular pathology mouse nonhuman North America *Parvoviridae parvovirus infection priority journal species distribution virus transmission female disease course degenerative disease / etiology controlled study *chronic kidney failure / *etiology cell inclusion Australia Article histopathology infection control animal tissue animal cell adaptive immunity |
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