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Conference/Presentation Title: | The efficiency of a novel asymmetrical cellulose triacetate dialysis membrane compared to a standard high-flux dialysis membrane; a pilot study. | Authors: | Foo S.E.;Polkinghorne K. ;Uhe M.;Kerr P.G. ;Sin H.K.;Kameshwar K.;Damasiewicz M. | Monash Health Department(s): | Nephrology | Institution: | (Kameshwar, Damasiewicz, Polkinghorne, Foo, Uhe, Sin, Kerr) Department of Nephrology, Monash Health (Damasiewicz, Polkinghorne, Kerr) Department of Medicine, Monash University (Sin) Department of Nephrology, Kwong Was Hospital | Presentation/Conference Date: | 19-Jan-2021 | Copyright year: | 2020 | Publisher: | Blackwell Publishing | Publication information: | Nephrology. Conference: 55th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, ANZSN 2020. Virtual. 25 (SUPPL 3) (pp 34), 2020. Date of Publication: December 2020. | Abstract: | Aim: To compare properties of a novel asymmetrical cellulose triacetate (ATA) dialyser (Solacia 190-H, Nipro) to a commonly used high-flux polysulfone dialyser (FX-80, Fresenius) in patients undergoing long-hour (>7 hours) haemodialysis (HD). Background(s): The ATA membrane is highly porous and less prone to performance degradation, compared to a conventional high-flux membrane, potentially resulting in enhanced clearance of middle and large-middle molecules, along with protein bound solutes. Method(s): 10 long-hour home HD patients were included in this randomized cross-over trial. Patients were randomized to 4 weeks of either the 190-H or FX-80 dialyser with subsequent cross-over to the other. The removal of small (urea, phosphate and creatinine), middle and large-middle molecules (beta-2 microglobulin [B2M], indoxyl sulfate [IS], albumin) and markers of inflammation (interleukin-6 [IL-6], malondialdehyde-modified low density lipoprotein [MDA-LDL]), were evaluated during the mid-week dialysis session of the fourth week of each dialyser sequence. All results are expressed as mean differences in corresponding reduction ratios (RR) between the FX-80 and 190-H dialysers after 8 hours of dialysis. Result(s): There was no significant difference in reduction in clearance of small molecules, with a RR difference for urea -2.43 (p = 0.19), creatinine -1.82 (p = 0.28) and phosphate -2.61 (p = 0.55). Similarly, there was no difference in clearance of middle and large-middle molecules with a RR difference for B2M 2.63 (p = 0.22), IS 2.48 (p = 0.69) and albumin -0.15 (p = 0.96). There was also no difference in expression of inflammatory markers with RR for IL-6 18.8 (p = 0.44) and MDA-LDL -8.0 (p = 0.3). Conclusion(s): Our study did not demonstrate a difference in clearance of small, middle and large-middle molecules, nor the expression of markers of inflammation between the FX-80 and H-190 dialysers. | Conference Start Date: | 2020-11-28 | Conference End Date: | 2020-12-02 | DOI: | http://monash.idm.oclc.org/login?url= http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/nep.13798 |
ISSN: | 1440-1797 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/28605 | Type: | Conference Abstract | Subjects: | controlled study dialysis membrane female gene expression genetic marker home dialysis human inflammation male *pilot study protein expression randomized controlled trial solute albumin beta 2 microglobulin *cellulose triacetate adult endogenous compound indican interleukin 6 low density lipoprotein malonaldehyde perfluorobutyltetrahydrofuran phosphate polysulfone urea *cellulose triacetate membrane creatinine clinical trial conference abstract *pilot study protein expression randomized controlled trial solute human home dialysis genetic marker gene expression female dialysis membrane controlled study adult male conference abstract clinical trial *cellulose triacetate membrane inflammation |
Type of Clinical Study or Trial: | Randomised controlled trial |
Appears in Collections: | Conferences |
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