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Title: | Duration of dexamethasone administration for the prevention of chemotherapy-induced nausea and vomiting - a systematic review and meta-analysis. [Critical Reviews in Oncology/Hematology] | Authors: | Markman B.;Raghunath A. ;Chandrasekara S.D.;Anthony S.N. | Institution: | (Raghunath, Markman) Monash Health, Victoria, Australia (Chandrasekara) Alfred Health, Victoria, Australia (Anthony) Melbourne Health, Victoria, Australia (Markman) Monash University, Victoria, Australia | Issue Date: | 7-Jul-2020 | Copyright year: | 2020 | Publisher: | Elsevier Ireland Ltd | Place of publication: | Ireland | Publication information: | Critical Reviews in Oncology/Hematology. 152 (no pagination), 2020. Article Number: 103012. Date of Publication: August 2020. | Journal: | Critical Reviews in Oncology/Hematology | Abstract: | Background: Chemotherapy-induced nausea and vomiting (CINV) is the most common non-haematological toxicity of chemotherapy. Method(s): A systematic review and meta-analysis comparing short course (1-2 days) with long course (3+ days) dexamethasone in preventing CINV was performed in accordance with the PRISMA statement. Result(s): 1535 articles were screened to identify the 11 studies included in the review. Nine studies of 1892 patients were included in meta-analysis. There was no significant difference in complete response of nausea and vomiting between a short or long course of dexamethasone (RR 0.98, 95 % CI 0.89-1.07, p = 0.58). There was a lower risk of adverse events with a short course of dexamethasone (RR 0.80, 95 % CI 0.64-0.99, p = 0.04). Conclusion(s): There was no significant difference between a short or long course of dexamethasone in preventing nausea or vomiting, but a short course was associated with fewer adverse effects. PROSPERO protocol: CRD42019133785Copyright © 2020 Elsevier B.V. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.critrevonc.2020.103012 | PubMed URL: | 32593142 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32593142] | ISSN: | 1040-8428 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/29167 | Type: | Review | Subjects: | *chemotherapy induced nausea and vomiting/dt [Drug Therapy] *chemotherapy induced nausea and vomiting/pc [Prevention] colorectal cancer/dt [Drug Therapy] constipation/si [Side Effect] disease severity drug use fatigue/si [Side Effect] headache/si [Side Effect] human meta analysis review systematic review *treatment duration treatment response *dexamethasone/ae [Adverse Drug Reaction] *dexamethasone/cb [Drug Combination] *dexamethasone/dt [Drug Therapy] granisetron/cb [Drug Combination] granisetron/dt [Drug Therapy] irinotecan/dt [Drug Therapy] stomach cancer/dt [Drug Therapy] advanced cancer/dt [Drug Therapy] adverse event anorexia/si [Side Effect] chemotherapy induced nausea and vomiting colorectal cancer constipation drug use fatigue headache dexamethasone [Adverse Drug Reaction] dexamethasone granisetron irinotecan stomach cancer advanced cancer adverse event anorexia human meta analysis Review stomach cancer / drug therapy systematic review *treatment duration treatment response headache / side effect colorectal cancer / drug therapy *chemotherapy induced nausea and vomiting / *drug therapy / *prevention anorexia / side effect adverse event advanced cancer / drug therapy fatigue / side effect drug use disease severity constipation / side effect |
Type of Clinical Study or Trial: | Systematic review and/or meta-analysis |
Appears in Collections: | Articles |
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