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https://repository.monashhealth.org/monashhealthjspui/handle/1/31875| Title: | Endotoxin-induced circulatory changes in the newborn brain: A review. | Authors: | Yu V.Y.H.;Walker A.M.;Feng S.Y.S. | Institution: | (Feng, Yu, Walker) Ritchie Centre for Baby Health Research, Monash Institute of Medical Research, Monash University, Clayton, Vic. 3168, Australia (Feng, Yu) Department of Pediatrics, Monash University, Monash Medical Centre, Clayton, Vic. 3168, Australia | Issue Date: | 16-Oct-2012 | Copyright year: | 2007 | Publisher: | Medcom Limited (18 Cheung Lee Street, Chaiwan, Hong Kong) | Place of publication: | Hong Kong | Publication information: | Hong Kong Journal of Paediatrics. 12 (2) (pp 111-117), 2007. Date of Publication: April 2007. | Abstract: | Endotoxin induces complex changes in the newborn cerebral circulation, including vasoconstriction by down-regulating endothelial nitric oxide synthase and stimulating the production of endothelin and cyclooxygenase-2 derived vasoconstrictors including thromboxane A2, while also promoting vasodilatation by increasing the expression of inducible nitric oxide synthase and cyclooxygenase-2 derived vasodilators. Together, these changes represent a complex dysregulation of the newborn cerebral circulation. This review considers the effects of neonatal endotoxaemia on cerebral circulatory changes and endothelium-derived factors, and their implications for cerebral circulatory control. | ISSN: | 1013-9923 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/31875 | Type: | Review | Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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