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Title: | Appearance of del(11q) in two patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and combination chemotherapy. | Authors: | Campbell L.J.;Catalano J.V.;Arkell K.;Rayeroux K.C.;Cole-Sinclair M.F. | Institution: | (Campbell, Rayeroux, Arkell) Victorian Cancer Cytogenetics Service, St. Vincent's Hospital, Melbourne, Vic., Australia (Catalano) Department of Haematology, Monash Medical Centre, Melbourne, Vic., Australia (Cole-Sinclair) Department of Haematology, Alfred Hospital, Melbourne, Vic., Australia (Campbell) Victorian Cancer Cytogenetics Service, St. Vincent's Hospital Melbourne, PO Box 2900, Fitzroy, Vic. 3065, Australia | Issue Date: | 18-Oct-2012 | Copyright year: | 2002 | Publisher: | Blackwell Publishing Ltd (9600 Garsington Road, Oxford OX4 2XG, United Kingdom) | Place of publication: | United Kingdom | Publication information: | British Journal of Haematology. 118 (1) (pp 243-245), 2002. Date of Publication: 2002. | Abstract: | Two acute promyelocytic leukaemia patients, treated with all-trans retinoic acid and combination chemotherapy, acquired a deletion of 11q within 12 months of diagnosis. One patient died in relapse, with both t(15;17) and del(11q) cell lines co-existing. Patient 2 remains in remission with del(11q) in 70% metaphases, despite normal marrow morphology. No deletion of the MLL gene was identified in the latter patient. The early appearance of a del(11q) is unusual, particularly without morphological evidence of myelodysplasia. We hypothesize that the del(11q) was therapy-induced but the absence of other genetic lesions has resulted in no accompanying morphological changes. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1046/j.1365-2141.2002.03553.x | PubMed URL: | 12100154 [http://www.ncbi.nlm.nih.gov/pubmed/?term=12100154] | ISSN: | 0007-1048 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/33043 | Type: | Article | Subjects: | *promyelocytic leukemia/dt [Drug Therapy] amsacrine/cb [Drug Combination] amsacrine/dt [Drug Therapy] antineoplastic agent/do [Drug Dose] antineoplastic agent/dt [Drug Therapy] cytarabine/cb [Drug Combination] cytarabine/do [Drug Dose] cytarabine/dt [Drug Therapy] idarubicin/cb [Drug Combination] idarubicin/dt [Drug Therapy] *retinoic acid/cb [Drug Combination] *retinoic acid/do [Drug Dose] *retinoic acid/dt [Drug Therapy] gene deletion antineoplastic agent/cb [Drug Combination] adult article bone marrow *cancer combination chemotherapy cancer recurrence cancer regression case report *chromosome deletion clinical feature controlled study death disease course human male myelodysplasia priority journal death disease course gene deletion human male myelodysplasia priority journal article adult *promyelocytic leukemia / *drug therapy bone marrow *cancer combination chemotherapy cancer recurrence cancer regression case report *chromosome deletion clinical feature controlled study |
Type of Clinical Study or Trial: | Case series or case report |
Appears in Collections: | Articles |
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