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Title: | IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. | Authors: | Kitching A.R. ;Holdsworth S.R. ;Tipping P.G. | Institution: | (Kitching, Tipping, Holdsworth) Centre for Inflammatory Diseases, Monash University, Monash Medical Centre, Clayton, Vic., Australia (Kitching) Department of Medicine, Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, Vic. 3168, Australia | Issue Date: | 19-Oct-2012 | Copyright year: | 1999 | Publisher: | Wiley-VCH Verlag (P.O. Box 101161, Weinheim D-69451, Germany) | Place of publication: | Germany | Publication information: | European Journal of Immunology. 29 (1) (pp 1-10), 1999. Date of Publication: 1999. | Abstract: | Glomerular crescent formation characterizes severe glomerulonephritis (GN). Evidence suggests that crescent formation results from a delayed-type hypersensitivity-like Th1 response. As IL-12 directs Th1 responses, we tested the hypothesis that IL-12 is important in crescentic GN. Neutralization of IL-12 attenuated crescent formation and cell-mediated injury in C57BL/6 mice sensitized to and challenged with sheep anti-mouse glomerular basement membrane (GBM) globulin. Recombinant IL-12 induced severe crescentic GN with enhanced Th1 responses in C57BL/6 mice in which non-crescentic GN was induced by injecting anti-GBM globulin into naive mice. BALB/c mice do not develop significant crescent formation in these models, due either to regulatory effects of IL-4, or to deficits in IL-12 production/responsiveness. Administering IL-12 to BALB/c mice with GN induced Th1 responses and crescent formation, whereas IL-4-deficient BALB/c mice did not develop cell-mediated crescentic injury when GN was induced in sensitized mice. These results establish a central role for IL-12 in severe crescentic GN. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/%28SICI%291521-4141%28199901%2929:01%3C1 | PubMed URL: | 9933080 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9933080] | ISSN: | 0014-2980 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/33571 | Type: | Article | Subjects: | controlled study *glomerulonephritis helper cell *kidney injury/et [Etiology] male mouse nonhuman priority journal glomerulus basement membrane antibody *interleukin 12/ec [Endogenous Compound] interleukin 4/ec [Endogenous Compound] recombinant interleukin 12 article animal experiment article *glomerulonephritis helper cell *kidney injury / *etiology male mouse nonhuman priority journal animal experiment controlled study |
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