Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/33929| Title: | Bactericidal activity and synergy studies of proton pump inhibitors and antibiotics against Helicobacter pylori in vitro. | Authors: | Turnidge J.D.;Midolo P.D.;Lambert J.R. | Institution: | (Midolo, Turnidge) Department of Microbiology, Monash Medical Centre, Melbourne, Vic., Australia (Lambert) Gastroenterology Research Group, Mornimton Peninsula Hospital, Melbourne, Vic., Australia (Midolo) Department of Microbiology, Monash Medical Centre, 246 Clayton Rd, Clayton, Vic. 3168, Australia | Issue Date: | 22-Oct-2012 | Copyright year: | 1997 | Publisher: | Oxford University Press (Great Clarendon Street, Oxford OX2 6DP, United Kingdom) | Place of publication: | United Kingdom | Publication information: | Journal of Antimicrobial Chemotherapy. 39 (3) (pp 331-337), 1997. Date of Publication: 1997. | Abstract: | The bactericidal activity of the proton pump inhibitors omeprazole and lansoprazole alone and in combination with a beta-lactam or macrolide antibiotic were investigated in vitro. Time-kill curves against Helicobacter pylori NCTC 11637 and a recent clinical isolate revealed significant concentration-dependent killing with all drugs other than amoxycillin. Combinations of proton pump inhibitor and erythromycin showed synergic activity. In contrast, proton pump inhibitor plus amoxycillin showed additive activity against the clinical isolate only. Bactericidal investigations of anti-helicobacter drugs in vitro may suggest optimum treatment strategies for this common infectious disease. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1093/jac/39.3.331 | PubMed URL: | 9096182 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9096182] | ISSN: | 0305-7453 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/33929 | Type: | Article |
| Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.