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https://repository.monashhealth.org/monashhealthjspui/handle/1/34064| Title: | Interleukin-1 receptor antagonism. | Authors: | Lan H.Y.;Nikolic-Paterson D.J. ;Atkins R.C. | Institution: | (Nikolic-Paterson) Department of Nephrology, Monash Medical Centre, Clayton, Vic. 3168, Australia (Lan, Atkins) Director of Nephrology, Monash Medical Centre, 246 Clayton Rd, Clayton, Vic. 3168, Australia | Issue Date: | 22-Oct-2012 | Copyright year: | 1996 | Publisher: | W.B. Saunders (Independence Square West, Philadelphia PA 19106-3399, United States) | Place of publication: | United States | Publication information: | Seminars in Nephrology. 16 (6) (pp 583-590), 1996. Date of Publication: 1996. | Abstract: | Interleukin-1 (IL-1) is a pro-inflammatory cytokine that exerts a wide range of biological effects. The recently identified IL-1 receptor antagonist (IL-1ra) has provided a tool for blocking IL-1 activity in vivo, leading to a detailed understanding of the role of this cytokine in the inflammatory response. The importance of IL-1 production in glomerulonephritis has been shown by the ability of IL-1ra treatment to suppress the induction and progression of experimental crescentic glomerulonephritis. Although further studies are required, IL-1ra treatment is an attractive adjunct therapy for patients with progressive glomerulonephritis. | PubMed URL: | 9125803 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9125803] | ISSN: | 0270-9295 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/34064 | Type: | Review | Subjects: | nonhuman pathogenesis priority journal review *rheumatoid arthritis/dt [Drug Therapy] sequence homology subcutaneous drug administration corticosteroid/dt [Drug Therapy] cytokine/ec [Endogenous Compound] immunosuppressive agent/dt [Drug Therapy] *interleukin 1/ec [Endogenous Compound] *interleukin 1 receptor *interleukin 1 receptor blocking agent/ct [Clinical Trial] *interleukin 1 receptor blocking agent/dt [Drug Therapy] prednisolone/dt [Drug Therapy] phase 3 clinical trial amino acid sequence clinical trial double blind procedure gene expression gene therapy *glomerulonephritis/dt [Drug Therapy] *glomerulonephritis/et [Etiology] human immune response inflammation *kidney injury/dt [Drug Therapy] *kidney injury/et [Etiology] multigene family *nephritis/dt [Drug Therapy] *nephritis/et [Etiology] *nephritis / *drug therapy / *etiology nonhuman pathogenesis phase 3 clinical trial priority journal review *rheumatoid arthritis / *drug therapy gene expression subcutaneous drug administration double blind procedure clinical trial amino acid sequence sequence homology gene therapy *glomerulonephritis / *drug therapy / *etiology human immune response inflammation *kidney injury / *drug therapy / *etiology multigene family |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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