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Title: | Changes in the temporal structure of periodic breathing with postnatal development in preterm infants. | Authors: | Berger P.J.;Adamson T.M.;Blanch N.;Wilkinson M.H.;Cranage S. | Institution: | (Wilkinson, Cranage, Berger, Blanch, Adamson) Inst. of Reproduction/Development, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia | Issue Date: | 25-Oct-2012 | Copyright year: | 1995 | Publisher: | Lippincott Williams and Wilkins (351 West Camden Street, Baltimore MD 21201-2436, United States) | Place of publication: | United States | Publication information: | Pediatric Research. 38 (4) (pp 533-538), 1995. Date of Publication: 1995. | Abstract: | The progressive decrease in the periodic cycle duration (PCD) of periodic breathing with postnatal age in term infants has been previously reported by a number of authors and is thought to be associated with peripheral chemoreceptor maturation. We hypothesized that a similar decrease should be observed in preterm infants. Therefore, in this study we measured the changes in PCD with postnatal age in a small group of preterm (n = 4) infants followed longitudinally (36 afternoon nap studies) over the first 6 mo postnatally. PCD declined in these infants from 17.1 +/- 3.3 s (mean +/- 2 SD) at 9 d to 9.8 +/- 3.2 s (mean +/- 2 SD) at 105 d. The regression slope was - 0.072 s/d. Beyond 105 d there was no change in PCD up to 6 mo postnatally. We found no significant difference between active and quiet sleep. These results are similar to results previously published in term infants but apparently contradict recent data on a group of preterm infants. Possible reasons for this discrepancy are discussed. By examining long epochs of periodic breathing in these infants we also identified characteristic changes in PCD and V/A ratio, defined as the duration of the ventilatory period divided by the duration of the apneic interval, V/A ratio fell from the start of an epoch from 1.21 +/- 0.08 (mean +/- SEM) to a minimum of 0.62 +/- 0.03 and then increased again to 0.8 +/- 0.05 at the end of the epoch. We conclude that important maturational changes occur in the neonatal respiratory control system during the first 6 mo postnatally and that these changes are reflected in a fall in PCD of periodic breathing over this period. We also conclude that the characteristic changes which occur in V/A ratio and PCD are consistent with a role for chemical stimuli in the genesis of periodic breathing. | PubMed URL: | 8559605 [http://www.ncbi.nlm.nih.gov/pubmed/?term=8559605] | ISSN: | 0031-3998 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/34170 | Type: | Article | Subjects: | breathing pattern chemoreceptor clinical article female fetus lung maturation human hypocapnia hypoxemia infant male *postnatal development *prematurity priority journal respiration control sudden infant death syndrome apnea newborn article *breathing disorder infant male newborn *postnatal development *prematurity priority journal respiration control sudden infant death syndrome human fetus lung maturation female clinical article chemoreceptor apnea hypoxemia *breathing disorder article hypocapnia breathing pattern |
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