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https://repository.monashhealth.org/monashhealthjspui/handle/1/34283| Title: | Impaired glucocorticoid induction of mononuclear leukocyte lipocortin-1 in rheumatoid arthritis. | Authors: | Dixey J.;Goulding N.J.;Mitra D.;Morand, Eric ;Jefferiss C.M. | Monash Health Department(s): | Rheumatology | Institution: | (Morand, Jefferiss, Dixey, Mitra, Goulding) Inflammation Research Group, Bath Inst. for Rheumatic Diseases, Trim Bridge, Bath, United Kingdom (Morand) Monash Rheumatology Unit, Monash Medical Centre, Locked Bag No. 29, Clayton, Vic. 3168, Australia | Issue Date: | 25-Oct-2012 | Copyright year: | 1994 | Publisher: | John Wiley and Sons Inc. (P.O.Box 18667, Newark NJ 07191-8667, United States) | Place of publication: | United States | Publication information: | Arthritis and Rheumatism. 37 (2) (pp 207-211), 1994. Date of Publication: February 1994. | Abstract: | Objective. To investigate leukocyte lipocortin-1 production in rheumatoid arthritis (RA). Methods. Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin-1 was measured by enzyme- linked immunosorbent assay. Results. Hydrocortisone induced significant increases in lipocortin-1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin-1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014). Conclusion. These results indicate that glucocorticoid- induced MNC lipocortin-1 production is impaired in RA. | PubMed URL: | 8129776 [http://www.ncbi.nlm.nih.gov/pubmed/?term=8129776] | ISSN: | 0004-3591 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/34283 | Type: | Article |
| Appears in Collections: | Articles |
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