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Title: | Transfer of donor anti-HLA antibody expression to multiple transplant recipients: A potential variant of the passenger lymphocyte syndrome?. | Authors: | MacDonald P.;Testro A.;Pavlovic J.;Sullivan L.C.;Westall G.P.;Snell G.I.;Kummrow M.;Hiho S.;Hudson F.;Cantwell L.;Mulley W.R.;D'Orsogna L. | Institution: | (Kummrow, Hiho, Hudson, Cantwell) Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, VIC, Australia (Hiho, Sullivan, Snell, Westall) Lung Transplant Service, Alfred Hospital, Melbourne, VIC, Australia (Mulley) Department of Nephrology, Monash Medical Centre, Clayton, VIC, Australia (D'Orsogna) Department of Clinical Immunology, Fiona Stanley Hospital, Perth, WA, Australia (Testro, Pavlovic) Liver Transplant Unit, Austin Hospital, Melbourne, VIC, Australia (MacDonald) Heart Transplant Service, St Vincent's Hospital, Sydney, NSW, Australia (Sullivan) Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia | Issue Date: | 7-May-2019 | Copyright year: | 2019 | Publisher: | Blackwell Publishing Ltd | Place of publication: | United Kingdom | Publication information: | American Journal of Transplantation. 19 (5) (pp 1577-1581), 2019. Date of Publication: May 2019. | Journal: | American Journal of Transplantation | Abstract: | Antibody-mediated rejection, whereby transplant recipient B cells and/or plasma cells produce alloreactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early posttransplant coexistence of a shared anti-HLA antibody profile in 5 solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the passenger lymphocyte syndrome. These findings have important implications for the consideration of all posttransplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients.Copyright © 2019 The American Society of Transplantation and the American Society of Transplant Surgeons | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/ajt.15262 | PubMed URL: | 30653828 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30653828] | ISSN: | 1600-6135 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/35667 | Type: | Article | Subjects: | female *graft recipient heart transplantation *HLA system human human tissue *immune deficiency immunoglobulin A deficiency immunosuppressive treatment internal carotid artery cardiopulmonary bypass kidney transplantation left hemisphere liver transplantation *lung donor lung graft rejection/dt [Drug Therapy] lung transplantation male middle aged molecular typing monoclonal immunoglobulinemia priority journal real time polymerase chain reaction kidney pancreas transplantation case report clinical article computed tomographic angiography *passenger lymphocyte syndrome adult alpha 1 antitrypsin deficiency ankylosing spondylitis antibody mediated rejection article brain angiography brain infarction bronchiectasis bronchoscopy retrospective study thorax radiography transbronchial biopsy azathioprine/dt [Drug Therapy] *HLA antibody/ec [Endogenous Compound] prednisolone/dt [Drug Therapy] tacrolimus/dt [Drug Therapy] male adult alpha 1 antitrypsin deficiency ankylosing spondylitis antibody mediated rejection Article brain angiography brain infarction bronchiectasis bronchoscopy cardiopulmonary bypass case report clinical article computed tomographic angiography female *graft recipient heart transplantation *HLA system human human tissue *immune deficiency immunoglobulin A deficiency immunosuppressive treatment internal carotid artery kidney pancreas transplantation kidney transplantation left hemisphere liver transplantation *lung donor lung graft rejection / drug therapy lung transplantation middle aged molecular typing monoclonal immunoglobulinemia priority journal real time polymerase chain reaction retrospective study thorax radiography transbronchial biopsy |
Type of Clinical Study or Trial: | Case series or case report |
Appears in Collections: | Articles |
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