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https://repository.monashhealth.org/monashhealthjspui/handle/1/35896| Title: | Cerebellar atrophy with Chiari malformation: An example of trans-synaptic degeneration?. | Authors: | Peters J.;Kempster P. ;Amukotuwa S.;Ding C. | Institution: | (Peters, Ding, Kempster) Neurosciences Department, Monash Medical Centre, Clayton, Australia (Amukotuwa) Department of Imaging, Monash Medical Centre, Clayton, Australia (Kempster) Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Australia | Issue Date: | 6-Nov-2019 | Copyright year: | 2019 | Publisher: | Churchill Livingstone | Place of publication: | United Kingdom | Publication information: | Journal of Clinical Neuroscience. 69 (pp 279-280), 2019. Date of Publication: November 2019. | Journal: | Journal of Clinical Neuroscience | Abstract: | A 23-year old man was found to have a Chiari Type 1 malformation and cerebellar atrophy. While this association has previously been described, the remote cerebellar atrophy is difficult to explain. We believe the answer lies with our finding of signal hyperintensity on MR imaging at the level of the inferior olives. This suggest hypertrophic olivary degeneration, caused by trans-synaptic degeneration following disruption to the Guillain-Mollaret triangle. Propagation of this process to the cerebellar Purkinje cells occurs in some cases. We describe a case in support of this hypothesis and review previously published evidence.Copyright © 2019 Elsevier Ltd | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.jocn.2019.08.005 | PubMed URL: | 31447362 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31447362] | ISSN: | 0967-5868 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/35896 | Type: | Article | Type of Clinical Study or Trial: | Case series or case report |
| Appears in Collections: | Articles |
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