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https://repository.monashhealth.org/monashhealthjspui/handle/1/36203| Title: | Vascular changes in fetal growth restriction: clinical relevance and future therapeutics. | Authors: | Sehgal A. ;Dahlstrom J.E.;Murthi P. | Institution: | (Sehgal) Monash Newborn, Monash Children's Hospital, Monash University, Melbourne, Australia (Sehgal) Department of Pediatrics, Monash University, Melbourne, Australia (Murthi) Department of Maternal Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital and Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, VIC, Australia (Murthi) Department of Physiology, Monash University and The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia (Dahlstrom) Anatomical Pathology, ACT Pathology, The Canberra Hospital and the Australian National University Medical School, College of Health and Medicine, Canberra, ACT, Australia | Issue Date: | 5-Mar-2019 | Copyright year: | 2019 | Publisher: | Nature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom) | Place of publication: | United Kingdom | Publication information: | Journal of Perinatology. 39 (3) (pp 366-374), 2019. Date of Publication: 01 Mar 2019. | Journal: | Journal of Perinatology | Abstract: | Fetal growth restriction (FGR) affects about 5-10% pregnancies and is associated with poorer outcomes in the perinatal period. Additionally, long standing epidemiological data support its association with chronic diseases such as hypertension and diabetes. Cardiac and vascular adaptations in response to chronic hypoxemia due to utero-placental insufficiency are hallmarks of fetal adaptations. Investigators have attempted to identify these changes in the placenta at the microscopic and molecular level. The ex vivo dual perfusion model of the placenta enables the study of placental haemodynamics in growth-restricted pregnancies. Persistent arterial abnormalities (thickness and stiffness) noted on vascular ultrasound during fetal life through to the young-adult age group for those affected by FGR, seem to be a plausible link between in utero events and chronic circulatory diseases. Using these, this review reflects current thought on vascular maladaptive changes in the FGR cohorts and the role in investigating current and future therapeutics.Copyright © 2018, Springer Nature America, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41372-018-0287-4 | PubMed URL: | 30518801 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30518801] | ISSN: | 0743-8346 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/36203 | Type: | Review | Subjects: | review survival rate tissue level *vascular disease angiotensin II/ec [Endogenous Compound] formylpeptide receptor/ec [Endogenous Compound] melatonin/dt [Drug Therapy] nitric oxide/ec [Endogenous Compound] placebo prostacyclin/ec [Endogenous Compound] sildenafil/cm [Drug Comparison] sildenafil/dt [Drug Therapy] pulmonary hypertension/dt [Drug Therapy] aging blood vessel tone cardiovascular disease cell proliferation drug tolerability histopathology human *intrauterine growth retardation/dt [Drug Therapy] intravascular ultrasound nonhuman oxidative stress placenta function preeclampsia protein expression protein synthesis placenta function preeclampsia protein expression protein synthesis pulmonary hypertension / drug therapy Review survival rate cardiovascular disease *vascular disease blood vessel tone aging tissue level cell proliferation drug tolerability histopathology human *intrauterine growth retardation / *drug therapy intravascular ultrasound nonhuman oxidative stress |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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