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https://repository.monashhealth.org/monashhealthjspui/handle/1/37633| Title: | Lyn, lupus, and (B) lymphocytes, a lesson on the critical balance of kinase signaling in immunity. | Authors: | Low M.S.Y.;Brodie E.J.;Tarlinton D.M.;Infantino S. | Institution: | (Brodie, Infantino, Low, Tarlinton) Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia (Low) Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia (Low) Immunology Division, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, VIC, Australia (Low) Department of Haematology, Monash Health, Monash Hospital, Clayton, VIC, Australia | Issue Date: | 13-Mar-2018 | Copyright year: | 2018 | Publisher: | Frontiers Media S.A. (E-mail: info@frontiersin.org) | Place of publication: | Switzerland | Publication information: | Frontiers in Immunology. 9 (MAR) (no pagination), 2018. Article Number: 401. Date of Publication: 01 Mar 2018. | Journal: | Frontiers in Immunology | Abstract: | Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as such represent an attractive therapeutic target. Lyn is a Src family tyrosine kinase that plays a major role in regulating signaling pathways within B cells as well as other hematopoietic cells. Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn-/- mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent advances in our understanding of the function of the Src family tyrosine kinase Lyn in B lymphocytes and its contribution to positive and negative signaling pathways that are dysregulated in autoimmunity.Copyright © 2018 Brodie, Infantino, Low and Tarlinton. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3389/fimmu.2018.00401 | Link to associated publication: | Click here for full text options | ISSN: | 1664-3224 (electronic) | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/37633 | Type: | Review | Subjects: | kinetics *lymphocyte nonhuman PIR-International Protein Sequence Database protein phosphorylation review RNA splicing sensitivity analysis sequence homology *signal transduction systemic lupus erythematosus T lymphocyte ubiquitination B lymphocyte receptor/ec [Endogenous Compound] BCR ABL protein/ec [Endogenous Compound] Bruton tyrosine kinase/ec [Endogenous Compound] carcinoembryonic antigen related cell adhesion molecule 1/ec [Endogenous Compound] CD19 antigen/ec [Endogenous Compound] cyclin D/ec [Endogenous Compound] Fc receptor IIb/ec [Endogenous Compound] glycogen synthase kinase 3beta/ec [Endogenous Compound] growth factor receptor bound protein 2/ec [Endogenous Compound] immunoglobulin A/ec [Endogenous Compound] immunoglobulin M/ec [Endogenous Compound] interferon regulatory factor 5/ec [Endogenous Compound] interleukin 12/ec [Endogenous Compound] interleukin 6/ec [Endogenous Compound] mitogen activated protein kinase 1/ec [Endogenous Compound] mitogen activated protein kinase 3/ec [Endogenous Compound] Myc protein/ec [Endogenous Compound] myeloid differentiation factor 88/ec [Endogenous Compound] non receptor protein tyrosine phosphatase 2/ec [Endogenous Compound] phosphatidylinositol 3 kinase/ec [Endogenous Compound] phosphatidylinositol kinase/ec [Endogenous Compound] phosphoinositide dependent protein kinase 1/ec [Endogenous Compound] protein kinase C/ec [Endogenous Compound] *protein kinase Lyn/ec [Endogenous Compound] protein p85/ec [Endogenous Compound] protein SH2/ec [Endogenous Compound] protein tyrosine phosphatase 1B/ec [Endogenous Compound] synaptotagmin I/ec [Endogenous Compound] toll like receptor 1/ec [Endogenous Compound] unindexed drug *lupus vulgaris adaptive immunity Akt signaling antibody production autoimmune disease autoimmunity B lymphocyte cell hyperplasia downstream processing genetic susceptibility genome-wide association study genotype phenotype correlation human hydrolysis immune dysregulation *immunity inflammation hydrolysis immune dysregulation autoimmunity inflammation kinetics *lupus vulgaris *lymphocyte nonhuman PIR-International Protein Sequence Database protein phosphorylation Review RNA splicing sensitivity analysis sequence homology *signal transduction systemic lupus erythematosus T lymphocyte ubiquitination autoimmune disease antibody production Akt signaling adaptive immunity *immunity B lymphocyte cell hyperplasia downstream processing genetic susceptibility genome-wide association study genotype phenotype correlation human |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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