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Title: | Cytokines in male fertility and reproductive pathologies: Immunoregulation and beyond. | Authors: | Indumathy S.;Pueschl D.;Bergmann M.;Schuppe H.-C.;Hedger M.P.;Loveland B.E.;Loveland K.L.;Klein B. | Institution: | (Loveland, Pueschl, Indumathy, Hedger) Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia (Loveland, Pueschl, Indumathy, Hedger) Department of Molecular and Translational Sciences, School of Clinical Sciences, Monash Medical Centre, Monash University, Clayton, VIC, Australia (Loveland) Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia (Klein, Pueschl, Indumathy, Bergmann) Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Giessen, Germany (Klein) Institute of Anatomy and Cell Biology, Justus Liebig University Giessen, Giessen, Germany (Loveland) Burnet Institute, Melbourne, VIC, Australia (Schuppe) Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Giessen, Germany | Issue Date: | 16-Dec-2017 | Copyright year: | 2017 | Publisher: | Frontiers Media S.A. (E-mail: info@frontiersin.org) | Place of publication: | Switzerland | Publication information: | Frontiers in Endocrinology. 8 (NOV) (no pagination), 2017. Article Number: 307. Date of Publication: 20 Nov 2017. | Journal: | Frontiers in Endocrinology | Abstract: | Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to restoring, preserving or restricting fertility in humans. This review discusses the growing understanding of how cytokines contribute to testicular function and maintenance of male reproductive health, and to the pathologies associated with their abnormal activity in this organ. Here we consider both cytokines that signal through JAKs and are regulated by SOCS, and those utilizing other pathways, such as the MAP kinases and SMADs. The importance of cytokines in the establishment and maintenance of the testis as an immune-privilege site are described. Current research relating to the involvement of immune cells in testis development and disease is highlighted. This includes new data relating to testicular cancer which reinforce the understanding that tumorigenic cells shape their microenvironment through cytokine actions. Clinical implications in pathologies relating to local inflammation and to immunotherapies are discussed.Copyright © 2017 Loveland, Klein, Pueschl, Indumathy, Bergmann, Loveland, Hedger and Schuppe. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3389/fendo.2017.00307 | Link to associated publication: | Click here for full text options | ISSN: | 1664-2392 (electronic) | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/38758 | Type: | Review | Subjects: | cancer survival review signal transduction spermatogenesis survival rate testis testis cancer tumor microenvironment vascularization bone morphogenetic protein 4/ec [Endogenous Compound] CD68 antigen/ec [Endogenous Compound] chemokine receptor CXCR4/ec [Endogenous Compound] CXCL13 chemokine/ec [Endogenous Compound] *cytokine/ec [Endogenous Compound] fibroblast growth factor 4/ec [Endogenous Compound] glycoprotein p 15095/ec [Endogenous Compound] growth differentiation factor 3/ec [Endogenous Compound] interleukin 10/ec [Endogenous Compound] interleukin 13/ec [Endogenous Compound] interleukin 4/ec [Endogenous Compound] interleukin 5/ec [Endogenous Compound] interleukin 6/ec [Endogenous Compound] mitogen activated protein kinase 1/ec [Endogenous Compound] mitogen activated protein kinase 3/ec [Endogenous Compound] mitogen activated protein kinase kinase 1/ec [Endogenous Compound] mitogen activated protein kinase kinase 2/ec [Endogenous Compound] octamer transcription factor 4/ec [Endogenous Compound] protein kinase B/ec [Endogenous Compound] Smad2 protein/ec [Endogenous Compound] Smad3 protein/ec [Endogenous Compound] STAT3 protein/ec [Endogenous Compound] stromal cell derived factor 1/ec [Endogenous Compound] transcription factor AP 2/ec [Endogenous Compound] transcription factor FOXP3/ec [Endogenous Compound] transcription factor NANOG/ec [Endogenous Compound] transforming growth factor beta/ec [Endogenous Compound] tumor necrosis factor receptor associated factor 1/ec [Endogenous Compound] tumor necrosis factor receptor associated factor 2/ec [Endogenous Compound] unindexed drug azoospermia blood testis barrier cell differentiation cytoarchitecture fertility *genital system disease human immune response immunopathology *immunoregulation inflammation JAK-STAT signaling *male fertility molecular interaction nonhuman survival rate spermatogenesis signal transduction JAK-STAT signaling vascularization *male fertility molecular interaction tumor microenvironment Review testis cancer testis *genital system disease human immune response immunopathology *immunoregulation inflammation nonhuman azoospermia blood testis barrier cancer survival cell differentiation cytoarchitecture fertility |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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