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https://repository.monashhealth.org/monashhealthjspui/handle/1/39928| Title: | The effects of hydroxychloroquine on endothelial dysfunction. | Authors: | Wallace E.M. ;Gurusinghe S.;Mockler J.C.;Lim R.;Rahman R.;Murthi P.;Singh H. | Monash Health Department(s): | Obstetrics and Gynaecology (Monash Women's) | Institution: | (Rahman, Singh, Gurusinghe, Mockler, Lim, Wallace) The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton 3168, Melbourne, VIC, Australia (Rahman, Gurusinghe, Mockler, Wallace) Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton 3168, Melbourne, VIC, Australia (Rahman) Department of Obstetrics and Gynaecology, Faculty of Medicine, National University of Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia (Murthi) Department of Medicine, School of Clinical Sciences, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton 3168, Melbourne, VIC, Australia | Issue Date: | 17-Jan-2017 | Copyright year: | 2016 | Publisher: | Elsevier B.V. | Place of publication: | Netherlands | Publication information: | Pregnancy Hypertension. 6 (4) (pp 259-262), 2016. Date of Publication: 01 Oct 2016. | Journal: | Pregnancy Hypertension | Abstract: | Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-alpha and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-alpha and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-alpha induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.Copyright © 2016 International Society for the Study of Hypertension in Pregnancy | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.preghy.2016.09.001 | ORCID: | Rahman, Rahana; ORCID: http://orcid.org/0000-0003-4161-6461 | Link to associated publication: | Click here for full text options | PubMed URL: | 27939463 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27939463] | ISSN: | 2210-7789 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/39928 | Type: | Article | Subjects: | tumor necrosis factor/ec [Endogenous Compound] adjuvant therapy adult angiogenesis antiinflammatory activity article clinical article controlled study down regulation *endothelial dysfunction female human immunomodulation in vitro study morbidity mortality *preeclampsia priority journal proteinuria endothelin 1/ec [Endogenous Compound] *hydroxychloroquine/pd [Pharmacology] in vitro study morbidity mortality *preeclampsia priority journal proteinuria angiogenesis adjuvant therapy adult antiinflammatory activity Article clinical article controlled study down regulation *endothelial dysfunction female human immunomodulation |
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