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https://repository.monashhealth.org/monashhealthjspui/handle/1/49891| Title: | RORing toward immunoregulation in glomerulonephritis? | Authors: | Lu C.;Kitching A.R. | Monash Health Department(s): | Centre for Inflammatory Diseases at Monash Health Nephrology Paediatric - Nephrology |
Institution: | (Lu, Kitching) Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, VIC, Australia (Kitching) Department of Nephrology, Monash Health, Clayton, VIC, Australia (Kitching) Department of Pediatric Nephrology, Monash Health, Clayton, Victoria, Australia |
Issue Date: | 15-Jun-2023 | Copyright year: | 2023 | Publisher: | Elsevier B.V. | Place of publication: | Netherlands | Publication information: | Kidney International. 104(1) (pp 28-31), 2023. Date of Publication: July 2023. | Journal: | Kidney International | Abstract: | CD4+ T cells that express forkhead box protein 3 are important in maintaining tolerance and restraining effector responses. Herrnstadt et al. use a model of rapidly progressive glomerulonephritis to examine the nature and role of forkhead box protein 3-positive and retinoid acid-related orphan receptor gammat-positive regulatory T cells. These cells are prominent in experimental glomerulonephritis, both locally and systemically, and are present in kidneys of people with anti-neutrophil cytoplasmic antibody-associated vasculitis. Functionally, despite their expression of retinoid acid-related orphan receptor gammat, associated with T-helper cell 17 cells, they regulate cellular immunity, both systemically and within the kidney.Copyright © 2023 International Society of Nephrology | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1016/j.kint.2023.04.018 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/49891 | Type: | Note | Subjects: | ANCA associated vasculitis CD4+ T lymphocyte experimental glomerulonephritis gene expression glomerulonephritis helper cell immunoregulation protein expression protein function rapidly progressive glomerulonephritis regulatory T lymphocyte forkhead transcription factor retinoic acid |
Type of Clinical Study or Trial: | Opinion, perspective or news |
| Appears in Collections: | Articles |
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